【摘要】 1986～1958年,对广东3个城市1～5岁儿童乙型肝炎病毒(HBV)感染做横断面调查的基础上,给新生儿普种乙型肝炎血源疫苗。出生后24小时内接种1针,1、6个月接种第、3针,每针10μg,共接种1万余名。免疫后抽查HBsAg阳性母亲新生儿血380人份,HBsAg阴性母亲新生儿血1466人份。同时采集同期出生的未免疫的新生儿血116份作为内对照。以放射免疫法(RIA)检测HBV指在。结果,新生儿免疫后1～5年,标化抗-HBs阳转率为67.3％～79.1％。免疫后1～5年HBsAg阳性率与免前HBsAg阳性率比较,其保护率为65.8％～92.1％;与平行内对照的HBsAg阳性率比较,保护率为58.6％～88.1％。且发现HBsAg阳性母亲的新生儿,随免疫年限延长,HBsAg阳性率有降低趋向。更多还原

【Abstract】 In three cities of Guangdong province we have studied a low dosage scheme HBV vaccine immunization for all infants from 1986-1988.A total of 10, 000 infants received three doses of 10μg/ml plasma-derived HB vaccine produced by Beijing National Institute of Biological Products. The vaccine was gived intramascularly by a 0-1-6 month schaduele. A total of 330 infants born to HBsAg positive mothers and 1,466 born to HBsAg negative mothers were tested in five successive years for HBsAg and anti-HBs.The result showed the anti-HBs remained high with a positive rate 72.8% by the fifth year, as compared with that 79.1% in the first year after vaccination. The HBsAg positive rate in immunized children dropped from 16.7% among the same age group children before immunization to 3.25% by the fifth year. The protective rate is 80.5%.更多还原