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支气管哮喘病儿外周血T细胞亚群的变化

THE CHANGES OF T CELL SUBSETS IN PERIPHERAL BLOOD FROM CHILDREN WITH BRONCHIAL ASTHMA

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【作者】 张秋业董增义王洁云单培芳林荣军王淑美

【Author】 Zhang Qiuye;Dong Zengyi;Wang Jieyun, et al Department of Pediatrics

【机构】 青岛医学院附属医院小儿内科青岛医学院附属医院小儿内科

【摘要】 应用OKT系列单克隆抗体对39例支气管哮喘病儿外周血T细胞亚群进行检测。结果发现,各型哮喘病儿均有T细胞亚群异常,发作期病儿T抑制/杀伤亚群细胞降低和T辅助/诱导亚群细胞增高同时存在,而间歇期病儿仅有T抑制/杀伤亚群细胞降低;发作期和间歇期病儿T辅助细胞/T抑制细胞比值均显著增高,发作期和间歇期病儿外周血中双标记细胞也明显增高。提示T细胞亚群异常为哮喘病儿的原发改变,可能为其免疫失调的内在基础。

【Abstract】 T cell subsets in peripheral blood from 39 children with bronchial asthma were detected using OKT monoclonal antibodies. During the onset stage of asthma, a decrease of T s/c subet cells and an increase of T h/i subset cells were present simultaneously, but during the silent stage there was only a decrease of T s/c subset ells. The ratio of the helper T cells to the suppressor T cells was significantly increased during both stages of asthma. The double-mark T cells in peripheral blood were also increased during both stages. The results suggested that the abnormality of T cell subsets was a primary change in children with bronchial asthma and this abnormality was possibly the internal basis of immunological irregulation.

【关键词】 T淋巴细胞辅助细胞抑制细胞哮喘儿童
【Key words】 T lymphocyteshelper cellsuppressor cellasthmachildren
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