【摘要】 应用免疫单向扩散法对75例脑血管病病人及32例正常人血清中多项补体成份进行了测定。结果显示,脑血栓形成病人补体C₃含量明显降低,而C_1q,C₅和B因子的含量明显升高,同时还发现血小板活性亢进,与对照组相比有显著性差异。脑动脉硬化和脑出血患者除B因子的含量较对照组明显升高外,其余4种补体成份均无明显变化。提示补体成份对免疫复合物清除能力的低下和促进血小板活性的增强可能是导致血栓形成的重要原因。更多还原

【Abstract】 Determination of serum complements were carried out in 75 patients with cerebro- vascular diseases and 32 normal controls. Among the patients were 26 with cerebral atherosclerosis, 34 with cerebral thrombosis and 15 with cerebral hemorrhage. The results showed that the levels of C₁ q, C₅ and B factor in the cases of thrombosis were signi- ficantly higher, and the levels of C₃ were significantly lower than those of the control group （P<0.001, P<0.05, P<0.001 and P<0.01 resqectively）. Determination of β-thromboglobulin （β-TG） and platelet factor 4 （PF4） was also carried out in 16 patients with cerebral thrombosis. It was found that their levels of β-TG and PF₄ were significantly higher than those of the control group （P<0.01） and their values of C₁ q and C₅ were positively correlated with the levels of β-TG and PF4. These results suggest that the complement system, especially the C₁ q and C₅, could induce the platelet to aggregate and release and might be the risk factors in the formation of cerebral thrombi更多还原