【摘要】 应用肾上腺素(EPN)、二磷酸腺苷(ADP)和胶原(COLL)三种致聚剂,对52例糖尿病(DM)患者的血小板聚集功能进行测定,同时测定了血浆纤维蛋白原(Fg)浓度,并按有无血管并发症进行分组比较,并对血小板聚集功能与Fg,空腹血糖(FPG)、胆固醇(CH)和甘油三酯(TG)的关系进行了观察。结果表明,ADP诱导的各组血小板聚集功能(PAgT)均明显升高(P<0.001～0.05),有血管并发症组较无血管并发症组显著升高(P<0.05);但对EPN和COLL诱导的PAgT无显著性差异。血浆Fg浓度显著高于对照组(P<0.001),在无血管并发症的早期即显著高于对照组(P<0.001)。ADP-PAgT与FPG,CH和TG无相关关系,但与Fg浓度则呈明显的正相关(r=0.565,P<0.002)。提示PAgT和Fg与血管病变密切相关,可能为其发病因素之一。更多还原

【Abstract】 Platelet aggregation induced by Epinephrine (EPN), adenosine diphosphate (ADP)and collagen (COLL) in 52 patients with diabetes was studied. The concentration ofplasma fibrinogen (Fg) was measured at the same time. The relationship betweenADP-induced platelet aggregative test (ADP-PAgT)and Fg, fasting plasma glucose(FPG), cholesterol (CH) and triglyceride (TG) was also observed. The patients fellinto two groups: one with vascular complications and the other without vascularcomplications. The results showed that ADP-PAgT was significantly higher in bothof the patient groups than in the controls, and higher in the group with vasculardiseases than in the group without vascular diseases. No significant difference wasfound in EPN-or COLL-induced PAgT. The concentration of plasma Fg in patientswith diabetes mellitus was higher than that in the controls. There was no correlationbetween FPG, CH, TG and ADP-PAgF, but there was a positive correlation betweenADP-PAgT and Fg. (γ=0.565, P<0.002). The results indicated that the closerelation between PAgT and Fg may be one of the causes of vascular diseases indiabetes.更多还原