【摘要】 应用流式细胞计测定分析了50例腮腺癌、36例良性涎腺肿瘤和5例正常延腺细胞核DNA含量,并探讨DNA指数(DI)、细胞分裂增殖指数(PI)与腮腺癌恶性度、生物学行为和预后等的关系。结果表明:不同年龄、性别、肿瘤大小和TNM分期之间DI、PI无显著性差异;DI和PI随肿瘤恶性度增高而增高,与淋巴结转移有关。伴发面瘫和无瘤生存期短于5年的腮腺癌的DI和PI显著高于面神经功能正常和无瘤生存期长于5年者。DI和PI是评价腮腺癌恶性度、生物学进为和预后的客观参数。更多还原

【Abstract】 Using flow-cytometry, the DNA content of the cells in 5 samples of normal salivary tissues, 36 cases of benign salivary tumors and 50 cases of parotid carcinoma was analysed. The results showed that the differences of DI and PI among different ages, sexes, tumor sizes, and TNM stages were not significant (P>0.05). The DI and PI of poorly differentiated parotid carcinomas were much higher than those of well differentiated parotid carcinomas (P<0.05). The DI and PI were closely related to the lymph node metastasis (P<0.001). The DI and PI of carcinomas with paralysis of facial nerves and with disease-free period less than 5 years were remarkably higher than those of carcinomas with non-kivo-Ived facial nerves and with disease-free period more than 5 years (P<0.01). The abovementioned results indicated that the DI and PI can reveal the cell proliferative kinetic characteristics and they also provide reliable and objective parameters for assessing degree of differentiation grade of malignancy, bilolgical behavior and prognosis of parotid carcinomas.更多还原