【摘要】 <正> 我国有学者曾对国内六个胃癌高发区进行了病因流行病学调查,发现这些地区的慢性胃病患者胃液中杂色曲霉的检出率最高。河北省赞皇县是胃癌高发区,胃癌年平均死亡率为59/10万。我们用小鼠微核试验和人外周血淋巴细胞程序外DNA合成(UDS)试验的方法,对该县慢性胃病患者胃液内更多还原

【Abstract】 The Aspergillus versicolor was separated from gastric juice of patients with chronicgastritis in Zanhuang County in Hebei Province, which is a high incidence area forstomach cancer. From A. versicolor culture an extract was prepared. After subcutaneousinjection of the extract into NIH mice, the micronucleus rate in blood lymphocyteswas greater than that in control group (P<0.01). Human peripheral blood lymphoctes(including monocytes) were treated in vitro with the extract at different dosages andthe resulted values of unscheduled DNA synthesis were much higher than that in controlgroup (P<0.01). The results suggest that the extract of A. versicolor is mutagenic orcarcinogenic and may play some role in the genesis of human stomach cancer.更多还原