【摘要】 酵母多糖刺激大鼠腹腔细胞合成与释放PGE₂及TXB₂,经短期培养（0～4h）,静止的细胞合成的PGE₂虽随时间的延长而增加,但无显著差别,而TXB₂的增长有明显差别。经酵母多糖刺激后二者均有显著增加,但以TXB₂之增加更迅速。角叉菜、硅胶、钙离子载体A₂₃₁₈₇均能显著促进培养24h的腹腔巨噬细胞合成与释放PGE₂和TXB₂。消炎痛、丹参素、硝苯吡啶及黄芩甙明显抑制A₂₃₁₈₇诱导的PGE₂合成增加。更多还原

【Abstract】 PGE2 has been recognized as an important mediator derived from macrophage in response to inflammatory stimulus. Among the cells involved in immune responses macrophage is the major cell to synthesis PGE2 and TXB2. The production of PGE2 and TXB2 can be regulated by different agents. In this study, elicited rat peritoneal macrophage cultured with or without different agents for certain hours then the culture fluids were assayed for PGE2 and TXB2 by radioimmuno assay after extracted with acetic ester. It has been shown that rest macrophages released little PGE2 but TXBz increased more rapidly than PGE2 in a time dependent fasion for 0-4 hours. After stimulation of zymosan for 0-4 h,the level of PGE2 and TXB2 were increased in the same fasion. Carrageenan, silica, A stimulated macrophage to increase PGE2 and TXB2 production. However, indomethacin danshensu, nifedipine and baicalin all inhibited PGE2 production by macrophages induced by更多还原