【摘要】 根据乙型肝炎病毒前S₁蛋白中的第21～47氨基酸决定簇人工合成肽P21～47。将P21～47与破伤风类毒素偶联成免疫原,免疫家兔获得了抗体。该抗体不仅可与P 21～47反应,还可与乙型肝炎病毒的PreS₁抗原发生反应。鉴于PreS₁与乙型肝炎病毒吸附于靶细胞表面受体有关,本抗体不仅可用于检测PreS₁抗原,还可研究病毒与受体间相互关系。更多还原

【Abstract】 A peptide was synthesized based on the 2l-47 amino acid sequence of Hepatitis B Virus PreSl protein. This peptide (p21-47) was cross-linked to tetanus toxoid and used to immunize rabbit. Rabbit P21-47 not only reacted with the peptide but also reacted with preSl (Large portein of HBV envelope) in Western blotting. Since preSl seems to be involved in attachment of HBV to target cells, this anti P21-47 has the potentiality in studying virus-receptor intereaction as well as for assaying PreS (?)antigen.更多还原