【摘要】 本文报告了通过单层细胞培养技术和直接计数的方法,观察在新型钙拮抗剂尼卡地平存在时,长春新碱和阿霉素对人恶性胶质瘤细胞——U₂₅₁ MG 的抑制效果。结果表明:低浓度无毒性作用的尼卡地平可以大大增强长春新碱对肿瘤细胞的抑制效果并能强化该药对瘤细胞作用的同步化。此时,再与阿霉素联合应用则抑制效果更加显著。这提示,在胶质瘤化疗中,钙拮抗剂与某些抗肿瘤药物联合应用可能成为一种克服胶质瘤细胞的耐药性和异质性,提高临床疗效的方法。更多还原

【Abstract】 The outcomes of inhibition of human malignantglioma cell line-U251 by vincrinstine and adriamy-cin combined with or without nicardipine,wereobseved in monolayer cell cuture andcount method.The experiment results showed thatthe inhibiting effect of vincrinstine on the gliomacell growth was increased by light density nontoxicnicardipine.It may be some coordination action onthe tumorous cells.When adriamycin was suppliedfollowing vincrinstine and nicardipine at 24 hourslater,the effect of the inhibition of glioma cellgrowth was more notable.It was suggested thatapplication of some antitumor agents with somecalcium antagonists perhaps was as a new kind ofchemotherapy for overcoming the resistance of gliomacells and improving the result in the managementof malinant gliomas.更多还原