【摘要】 本文对10例NIDDM进行了黎明现象测试,受试者于午夜至6:00～6:30a.m.保持睡眠状态,0:30～8:00a.m.每30分钟采血一次,作FBG、血浆INS、GH（自0a.m.开始采血）、F、E、NE及血清TT₃测定。结果示FBG于4:00a.m.后开始上升,于7:00a.m.达最高值;INS于0～5:00a.m.逐渐下降,且与增高的血糖浓度无相关。0a.m.时的GH高峰值与增高的血糖浓度成正相关。F（3:00a.m.后）、NE、E（4:00a.m.后）分泌浓度均呈有意义的增高,但与增高的血糖浓度均无相关。更多还原

【Abstract】 To assess whether the dawn phenomenon occurs in non-insulin-dependent diabetes mellitus (NIDDM), we determined plasma concentrations of glucose, insulin and counterregulatory hormones (GH and cortisol) as well as catcchol-amine and TT3 at 30-minute intervals between 0:30 a.m. and 8:00 a.m. (GH was determined from 0 a.m.) in 10 NIDDM cases. After 4:00 a.m., plasma glucose increased significantly (P<0.05). Plasma insulin gradually decreased from 0:30 a.m. to 5:00 a.m., then maintained at that low level until 7:00 a.m. (P>0.05). Plasma GH (0a.m. to 2:00 a.m.), cortisol (after 3:00 a.m.), catecholamine (after 4:00 a.m.) but not TT, increased significantly since 1:00 a.m. (P<0.01 or 0.05). The increases of plasma glucose were significantly correlated with the plasma growth hormone peaks (r = 0.70, P<0.05), but not with the changes in plasma cortisol, insulin and serum catecholamine as well as TT3.We concluded that dawn phenomenon in NIDDM begins earlier than non-diabetic individuals. The nocturnal surges of growth hormone may play a role in the mechanism of dawn phenomenon.更多还原