【摘要】 比较了当机体摄入不同辐射体核素¹³⁴Cs或¹⁴⁷Pm后,在骨组织中的滞留特性诱发体细胞中骨髓细胞的染色体畸变和PCE的微核形成效应。研究表明,机体摄入¹³⁴Cs后在持续7周时间的观察中,发现其在骨组织中的滞留可随时间的增长而迅速下降,拟合的滞留方程为:R(t=0.0029e^-0.121t,可见在骨中的滞留半减期只有5.73d。而¹⁴⁷Pm在相应实验阶段中在骨组织的滞留量则随观察时间的延长而呈持续的选择性蓄积,且沉积后的转移极慢,拟合的滞留方程为;R（t）=115.7977e^0.0002t-55.0212e^-0.7516t,可见在骨中的滞留半减期竟长达3465d之久。所以¹³⁴Cs在骨组织的相对滞留量和累积吸收剂量贡献都远低于¹⁴⁷Pm。¹³⁴Cs或¹⁴⁷Pm均可诱发骨髓细胞染色体畸变和PCE的微核形成效应。但在比较相应放射性活度时,¹³⁴Cs所诱发的骨髓细胞染色体畸变率和PCE的微核形成率效应,都较¹⁴⁷Pm为低。更多还原

【Abstract】 The purpose of the present study was to ascertain comparative retention of ’134Cs or 147Pm in skeleton on induction of chromosome aberrations and PCE’s micronucleus formation in bone marrow cells. Results indicated that after iy -signal nuclide 134Cs, through 7 weeks observation, the retention data in skeleton could be well described by an exponential expression. R(t) = Q. 0029e~?12 ’’ ?Where the retention T,/2 was only 5.73 d. The retention data of 147Pm in keleton could be described by an expressions. ^?(f)= 115.7977e~?0002’?55.0212e~?7616’ ?Where the retention T] 2 was prolonged to 3465 d. Experiments indicated that the retention value and the absorption dose of 147Pm in skeleton were significantly higher in comparison with 134Cs.Both internal contamination f "4Cs or U7Pm could induce chromosome aberrations and PCE’s micronucleus formation in bone marrow cells. Among the types of chromosome aberrations -of bone marrow cells induced by 134Cs or U7Pm included gap, chromatid breakage, chromosome breakage and translocation. Moreover, the chromosome -aberration rates were elevated when the intake of radioactivity of 134Cs or ’ 47Pm were enlarged. At the same time, chromosome fragment of bone marrow cells also induced by ’ 14Cs or ’ i7Pm only through high radioactive contamination. Studies showed that chromosome translocation was appeared only through high radioactivity of 147Pm contamination. By comparing with 147Pm, however, the induction of chromosome aberrations and PCE’s micronucleus formation rates on bone marrow cells induced by 134Cs was quite low.更多还原