【摘要】 实验中观察了当机体摄入不同放射性活度的重核裂片¹⁴⁷Pm时,在睾丸中的滞留过程诱发精子畸形效应以及基因突变效应。实验结果发现,当¹⁴⁷Pm由静脉摄入机体3.7×10²～1.85×10⁵Bq/g后在持续50d的观察中,可在BALB/C小白鼠睾丸中受到6.95×10^-2～2.25Gy的β粒子辐照。且其诱发基因突变的放射遗传毒理效应可随睾丸受照剂量的加大而增升,引起活胎率下降,胚胎吸收数增加。至于显性骨骼突变发生率与睾丸中¹⁴⁷Pm累积吸收剂量间呈正相关,其关系式为:B=20.68+35.48D;而在诱发精子畸形观察中,其量效关系式为:S=10.8705D^0.5224+3.1768。更多还原

【Abstract】 The purpose of the present study was to ascertain 147Pm retention in testis and its radiogenotoxicological effects of gene mutation through varying radioactivities of internal exposure. Especially the accumulation of 147Pm in testis induces the dominant lethal, dominant skeletal mutation and abnormalities in sperm. Studies indicated that the cumulative absorption dose in testis increases as the internal exposure of 147Pm increases. The internal exposure of 147Pm can destroy the genetic materials and raise the rates of dominant lethal and dominant mutation of skeletal abnormalities in the offspring. The relationship between the rate of dominant skeletal mutation (B) and accumulated radioactivities of ’4 7 Pm (D) in testis can be described by a linear equation that is B=20.68 + 35.48 D. The relationship between abnormalities of the sperm and the cumulative dose from ’4 7 Pm in testis can be expressed by the follwing equation. 5=10.8705 D?6ZZ4 + 3 .1768.更多还原