【摘要】 本文首次报告用吡哌酸制成水溶性基质的栓剂,测定体外释放度,结果吡哌酸栓于40min时溶出率为90%,60min时溶出率为92.64%。60min内溶出速率常数Kr为0.9953,T₅₀为13.04±1.55,Td为20.15±2.53,T₉₀为54.29±9.23,m为0.8418±0。07.β为12.5354,R为0.9948±0.0071.崩解时限与T₅₀,Td之间具有较好的相关性, 各料间无明显差异（P>0.01）。更多还原

【Abstract】 The release of pipemidic acid from suppositorywith water soluble base was studied. 90% of drugreleased in 40 min. and 92.64% in 60 min. Theconstant of dissolution rate in 60 min Kr was 0.9953,T₅₀ 13.04±1.55. T_d 20.15±2.53, T₉₀ 54.29±9.23, m0.8418±0.07,β12.5354, R 0.9948±0.0071.更多还原