【摘要】 本文对长时间（平均5～6年）接受吩噻嗪类药物治疗的慢性精神分裂症患者血清HDL及其亚组分中胆固醇含量进行了分析。结果显示:精神分裂症病人HDL-C水平比正常对照组明显降低（P<0.005）,其HDL亚组分变化主要表现在HDL₃-C显著性降低（P<0.001）,而HDL₂-C不降低。作者认为:吩噻嗪类药物能引起HDL-C水平降低,并对可能作用机制进行了探讨。更多还原

【Abstract】 The concentrations of high density lipoproteincholesterol and subfraction were investigated in pati-ents receiving phenothiazine for long periods (average5～6 years). The results showed that high densityliporotein cholesterol(HDL-C) levels were significantlylower(P<0.005) in the patients than in the normalcontrol. The HDL subfraction indicated that HDL-Cwas significantly lower(P<0.001) in the patients thanthe normal control, whereas HDL-C was not. Wesuggest that significantly low HDL-C level may becaused after the administration of phenothiazine.The mechanism of HDL-C lowering is discussed.更多还原