【摘要】 用DEAE-cellulose DE-52柱层析分离浙江蝮蛇蛇毒,用其中一组份给已经发生动脉粥样硬化的鹌鹑做静脉注射(隔日1次)。7周后发现此组份可使血清胆固醇含量下降,凝血时间延长,并降低肝脂肪化程度。此组份含二种主要蛋白,分子量为63000和51000,后者有精氨酸酯酶活性,二者均有纤溶酶活性。更多还原

【Abstract】 The venom of agkistrodon halys was separated with DEAE-cellulose chro-matography. The pooled protein fraction of the separation were injected intra-venously into the quail with aortic atherosclerosis induced by dietary cholesterol.After 7 weeks of injections of the fraction on every the other day, the resultsshowed that the lowering of serum cholesterol, prolonged blood clotting time andreduced fatty liver uas slgnificantly. This venom fraction contained two majorcomponents.The molecular weight of the big cre was (3000, and the other onewas 51000. The small one had arginine osterase activity. The two proteins hadfibronolytic activity.更多还原