【摘要】 以6-取代-4-羟基喹啉-3-甲酸为侧链酸,用氯代甲酸异丁酯或氯代甲酸乙醋为酰化剂与头孢菌素母核,7-ACDA、7-ACA、7-ACT和7-ACD缩合,合成了四个新的7β-(6-取代-4-羟基喹啉-3-甲酰胺)头孢菌素类化合物,通过溶媒转提,葡聚糖凝胶(SephadexLH-20)柱层析及冷冻干燥处理得到纯品。用元素分析、红外光谱及核磁共振谱确证了新化合物的结构。更多还原

【Abstract】 A series of new 7β-（6-substituted-4-hydroxy-quinoline-3-forraamido）-ccphalosporins were designed and prepared by direct condensation of the 7β-amino group of 7-ADCA, 7-ACA, 7-ACT and 7-ACD with 6-subsituted-4-hydroxy-quinoline-3-carboxylic acids, using chloroformates as acylating agents. Isolation and purification were fulfilled by treatment with solvent and Sephadex LH-20 column chromatography. Four novel 7β-（substituted-4-hydroxy-quinolinc-3-formamido）-ccphalosporin derivatives (Ⅱ_1-4) were synthesized and their structures were determined by elementary analysis, IR and ¹HNMR更多还原