【摘要】 本文分离并研究了山茱萸总甙、熊果酸和马钱子素的免疫药理性质。体内外实验结果都表明,总甙明显抑制小鼠淋巴细胞转化、LAK细胞生成和体内服用抑制白细胞介素2(IL-2)的产生,是一种免疫抑制剂。熊果酸能快速有效杀死培养细胞,故使培养淋巴细胞几乎完全失去淋转、IL-2生成和LAK细胞产生的能力,是一种杀细胞药物;但腹腔注射熊果酸的小鼠上述三种免疫指标明显提高。马钱子素对免疫反应有双向作用,促进IL-2的产生。更多还原

【Abstract】 The immunopharmacological effects of the total glucosides, ursoric and and loganin from Japanesecornel Dogwood (Cornus officinalis) were studied.The results showed that the total glucosides both in vitro and in vivo potentially inhibited mouse Lymphocyte transformation, the induction of lymphokiae-activated killer (LAK) cells as well as in vivo production of interleukin 2(IL-2) Meanwhile ursoric acid could rapidly kill the cells when they were cultured together. So like n cytolysin, it destroyed the lymphocyte blast and produced IL-2. But these abilities of lymphocytes from mice, intraperitoneally injected with ursoric acid, raised obviously. Therefore this component of natural origin can promote immune reactions. Loganin also potentiated IL-2 production and other immune activities.更多还原