【摘要】 本文观察了失血性休克犬的垂体—甲状腺轴的功能状态,发现休克犬的血清T₄、T₃较休克前降低,rT₃升高,而TSH变化不大。休克犬经多巴胺（DA）治疗后,其血清T₄、T₃低下更为明显,TSH亦较休克前明显降低（P<0.001）,rT₃变化不大。本结果说明①休克犬可出现低T₃、T₄综合征,但垂体功能正常;②休克犬用DA治疗后可出现继发性垂体甲状腺功能减退,故DA可影响垂体—甲状腺轴的功能。本研究尚证明DA在体外并不影响血清T₄、T₃和TSH浓度,且DA不易通过血脑屏障,所以,提示DA可能是直接作用于腺垂体影响TSH的合成或分泌。更多还原

【Abstract】 The pituitary-thyroid axis in dogs of hemorrhagic shock was studied by determination of serum T₄, T₃, rT₃ and TSH. Comparing with pre-shock condition, in shock dogs without dopamine （DA） treatment, serum T, and T₃ were decreased, rT₃ incre ascc and TSH unchanged. But in shock dogs treated by DA, serum T₄ and T₃ were much lower than those in shock dogs without DA and serum TSH was significantly lower （P<0.001） comparing with pre-shock condition. These results indicate: 1, lower T₃, T, syndrome is happened in shock dogs, 2, shock dogs treated by DA can resulted in secondary hypothyroidism and DA can affect the state of pituitary-thyroid axis. It has been found that DA had no effect on the concentrations of serum T₄, T₃ and TSH in vitro. This suggestes that DA directly affects synthesis and secretion of TSH.更多还原