【摘要】 <正> 雷公藤别名黄藤,系卫矛科植物雷公藤(Tripterygium wilfordii Hook.f.)。其根有舒筋活血,祛风湿,消肿止痛的功效,多用于类风湿关节炎的治疗。根皮中含有生物碱、甙、萜以及其它成分,其中多种二萜内酯成分有抗肿瘤活性和免疫更多还原

【Abstract】 A diterpenoid-lactone, white thin crystals, C₂₀H₂₄O₃, m/z: 312 （M⁺）, mp 222～223℃, UVλ_max （EtOH）217 （logε4.36）nm, has been isolated from the ethyl acetate extract of the roots of Tripterygium wilfordii Hook. f., in a yield of 0.025‰. Its structure was elucidated by spectral analysis(UV, IR, MS, ¹HNMR and ¹³CNMR) and X-ray SCD. It is the known triptophenolide with revision of structure.Triptophenlolide was shown to have obvious inhibiting effects on lymphocyte and IgG （P<0.01） when mice and rats were given ig 1.5 mg/kg. The total complements in blood serum was increased. When BALB/C mice were given ig 1.5 mg/kg, the ear oedema induced-by dimethyl benzene was significantly inhibited （P<0.01）; The ear oedema induced by croton oil in SD rats at a dose of ig 1.0 mg/kg was also significantly inhibited （P<0.05）. The vitamine C content of the adrenal gland was reduced in mice at a dose of 1.5 mg/kg. The ig LD₅₀ of triptophenolide was greater than 30mg/kg.更多还原