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茜草中抗菌活性成分的研究

STUDIES ON ANTIBACTERIAL CONSTITUENTS FROM THE ROOTS OF RUBIA CORDIFOLIA L

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【作者】 乔亚芳王素贤吴立军李铣朱廷儒

【Author】 YF Qiao, SX Wang, LJ Wu, X Li and TR Zhu (Department of Natural Products, Shenyang College of Pharmacy, Shenyang, 110015)

【机构】 沈阳药学院天然药物研究室沈阳药学院天然药物研究室 沈阳 110015沈阳 110015沈阳 110015

【摘要】 从茜草根中分得十二个化合物。通过理化性质及光谱分析,确定了八个已知化合物和一个新化合物(Ⅴ),Ⅴ的结构为1,3,6-三羟基-2-甲基蒽醌-3-O-(O-6′-乙酰基)-β-D-吡喃葡萄糖甙(▽)。

【Abstract】 Twelve compounds were isolated from the roots of Rubia cordifolia L.. Nine of them were established by chemical and spectroscopic methods te be alizarin (Ⅰ), 1-hydroxy-2-methyl-9, 10-anthraquinone (Ⅱ), 1, 3, 6-trihydroxy-2-methyl,-9, 10-anthra-quinone-3-O-(6’-O-acetyl)-α-L-rhamnosyl(1→2)-β-D-glucoside (Ⅲ), 1, 3, 6-trihydrozy-2-methyl-9, 10-anthraquinone-3-O-α-L-rhamnosyl(1→2)-β-D-giucoside(Ⅳ), 1, 3, 6-trihydrozy-2-methyl-9, 10-anthraquinone-3-O-(6’-O-acetyl)-β-D-glucoside(Ⅴ), 2-carbomethoxy -3-prenyl-1, 4-naphthohydroqumone d1-β-D-glucoside(Ⅵ), rubimalim(Ⅶ), β-sitosterel (Ⅷ) and daucosterol (Ⅸ), among them, Ⅴ is a nwe compound and Ⅸ was obtained: from this genus for the first time. Ⅲ, Ⅵ and Ⅶ showed certain antibacterial activities.

【基金】 国家自然科学基金
  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,1990年11期
  • 【被引频次】27
  • 【下载频次】328
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