【摘要】 从3091株酵母菌中筛选出一株Candida sp K₁₁,在加有半胱氨酸的培养基中培养的菌体,每克干细胞含18mg谷胱甘肽（GSH）。以K₁₁为出发株,经紫外线诱变,在GSH代谢类似物乙硫氨酸平板上选得抗代谢类似物突变株K₁₁UE126,其胞内累积GSH的量较出发株高出49.7％,且在其培养基中不必加入半胱氨酸。更多还原

【Abstract】 From 3091 strains o f yeast, a strain of Candida sp K₁₁ was selected which can produce 18 mg glutathione （ GSH ） by one gram of the dried cells in the presence of L-CySH in the culture medium. The original strain K₁₁ was subjected to mutagenesis by ultraviolet irradiation and a strain of analogue-antimetabolic mutant K₁₁ UE 126 was selected on the plate of GSH metobolic analogue ethionine. The content of GSH in the K₁₁ UE 126 cells increased by 49.7% over the original strain K₁₁ even without adding L-CySH in the culture medium.更多还原