【摘要】 本文观察了[D-Ala⁶,Pro⁹-Ethylamide¹⁰]-LHRH（LHRH-A）对孕中期大鼠的抗妊娠作用。结果显示:在孕9～11d sc 200μg/d LHRH-A,血浆孕酮水平自第二次给药后明显下降（P<0.05）,给药大鼠均流产终止妊娠;LHRH-A的抗妊娠作用可被醋酸甲地孕酮所拮抗;LHRH-A对体外培养的假孕大鼠和孕d 9大鼠黄体细胞分泌孕酮有明显的直接抑制作用。更多还原

【Abstract】 In the present study, the antipregnancy effect of( D-Ala⁶, Pro⁹-Ethylamide¹⁰)LHRH （LHRH-A）on midgestational rats was observed The results indicate that LHRH-A could terminate pregnancy of all experimented rats by abortion after subcutaneous administration of 200μg LHRH-A（dissolved in vegetable oil）once a day at days 9 to 11 of their pregnancy. It was also found that the serum progesterone level was significantly lowered after the administration ofLHRH-A （P<0.05）;the concomitant administration of megestrol acetate with LHRH’-A could almost completely block the antipregnancy effect of LHRH-A on the midgestational rats; LHRH-A showed a strong direct inhibitory effect on luteal cell progesterone secretion in pseudopregnant and midgestational rats. Hence, it is considered that the probable mechanisms for the antipregnancy effect ofLHRH-A may be mainly due to the decrease of serum progesterone level caused by the direct inhibitory effect of LHRH-A on midgestational corpus luteum progesterone production.更多还原