【摘要】 本文将导数光度法推广到互补三刺激值法领域,成功地同时测定了复方氯丙那林片中三个主要成分盐酸氯丙那林、盐酸溴已新及盐酸去氯羟嗪的含量。利用一阶导数基本上抑制了基体的干扰,结合添加技术,克服了因含量低和吸收系数低的盐酸氯丙那林的定量困难。本文还对片剂中三成分在人工胃中的溶出进行初步的动态研究,借助自行开发的软件,可实现参量选择、立时以表格形式报告结果和打印出溶出过程中各成分含量随时间相对变动的轨迹图。更多还原

【Abstract】 cloroprenaline hydrochloride (a), bromhexine hydrochloride (b) and decloxizine hydrochloride (c) are three main components in clorprenaline compound tablet. The serious overlapping bands of their absorption spectra cause the interference in the determinations, especially the component of (a) which has both minor content and low absorption coefficient, thus making the analysis difficult. In this paper, the interference from matrix is eliminated by using first order derivative transformation. In combination with complementary tristimulus method and with the technique of additions, the concentrations of three components in tablets can be suecessfully determined simultaneously. A software developed in this laboratory makes possible the ease of parameter selection, reporting data in various formats and printing figures of dissolution process, showing a clear locus. This method will be of value to quality control in manufacturing process and to the research of the dissolution dynamics of tablets in simulated stomach.更多还原