【摘要】 <正> 细辛醚(Asarone)主要存在于草药石菖蒲(Acorus gramineus soland)中,其含量占石菖蒲挥发油的64.6～86.0％。该油具有镇静、健胃、化痰、平喘等功效。石菖蒲挥发油中主要含β-细辛醚(1A,Z-细辛醚),而药理证明,止咳平喘的有效成分为α-细辛醚(1B,E-细辛醚)。与药理作用不同,含β-细辛醚的挥发更多还原

【Abstract】 Stereoselective synthesis of asarone by the reaction of 2, 4, 5-trimethoxy benzalde-hyde and the appropriate Grignard or Wittig reagent under different conditions was deseri-bed. In the approach with Grignard reaction, the major product was α-(E-) asarone, whilethe major product was either α-(E-) or β-(Z-) asarone in the Wittig approach depending onthe reaction conditions.更多还原