【摘要】 观察了向大鼠侧脑室微量注射雨蛙肽对由束缚浸水引起的大鼠应激性胃粘膜损伤的影响,并初步探讨了其作用机理。结果表明,侧脑室注射一定剂量的雨蛙肽(1.0～4.0ng)有明显的抗应激性胃粘膜损伤作用,这种作用可被预先侧脑室注射纳络酮所阻断,而预先侧脑室注射酚妥拉明、心得安及阿托品对雨蛙肽的作用无影响。提示,在雨蛙肽的抗应激性胃粘膜损伤作用中有中枢的吗啡受体参与。更多还原

【Abstract】 Effect of intracerebroventricular micro injection of caerulein on water-immersion induced gastric mucosal lesion was studied in rats. Injection of caerulein(1.0—4.0 ng/rat)into cerebroventricule significantly inhibited the stress-induced gastric mucosal lesion. Naloxone injected into the ventricle abolished the inhibiting effect of caerulein on gastric mucosal lesion. But injections of phentolamine, propranolol and atropine into the ventricle did not influence the effect of caerulein. It is indicated that the inhibiting effect of caerulein on gastric mucosal lesion is responsible for central morphine receptor.更多还原