【摘要】 ATP-MgCl₂和维拉帕米（Ver）抑制去甲肾上腺素（NE）和KCl所致兔主动脉条收缩反应,使量-效曲线非平行右移,压低最大收缩反应,说明是非竞争性拮抗,而单纯ATP和单纯MgCl₂的拮抗作用不明显。ATP-MgCl₂和Ver选择性抑制电压依赖性钙通道（PDC）,抑制细胞内Ca⁺⁺的释放,但对受体启动性钙通道（ROC）的抑制作用不明显。单纯ATP和单纯MgCl₂的作用均不如ATP-MgCl₂和Ver。更多还原

【Abstract】 The effects of ATP-MgCl₂, simple ATP and MgCl₂ on the contraction induced by norepinephrine（NE） or KCI were studied on the rabbit aortic strips, and the calcium antagonist verapamil（Ver）was used for comparison. ATP-MgCl₂ or Ver inhibited the contractions evoked by NE or KCI; they shifted dose-response curves for NE or KCI to the right in a non-parallel fashion, and depressed their maximal responses, showing noncompetitive antagonism. While in the ATP or MgCl₂ group, there were no apparent changes. ATP-MgCl₂ or Ver inhibited selectively potential-dependent Ca²⁺channel （PDC）. Both ATP-MgCl₂ and Ver inhibited the release of intracellular Ca²⁺, but had no influence on inhibiting action of receptoroperated Ca（2+） channel（ROC）; the action of the former was more potent than that in the ATP group and MgCl₂ group. This shows that both ATPMgCl₂ and Ver block the release of calcium from intracellular storage.更多还原