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糖芥总甙对豚鼠左心房生理特性的影响
EFFECTS OF ERYSIUM CHEIRANTHOIDES L TOTAL CARDIAC GLYCOSIDES ON PHYSIOLOGICAL PROPERTIES OF GUINEA PIG LEFT ATRIA
【摘要】 糖芥总甙（ETCG）对离体豚鼠左心房肌产生剂量依赖性的正性肌力作用,pD2为7.94。ETCG（0.17mg/L）提高左心房肌兴奋性和肾上腺素诱发的自律性。ETCG（0.01～0.17mg/L）显著延长功能性不应期。
【Abstract】 Total cardiac glycosides isolated from dry fruit of Erysium chei- ranthoides L ( ETCG ) possesed positive inotropic effect. Its effects on the physiological properties of guinea pig left atria were studied. in this paper. The effects of ETCG on dose-response curve were investigated. The results showed that ETCG increased contractility of left atria significantly and dose-dependently .The pD2 value was 7.94. ETCG ( 0.17mg/L)increased significantly excitability and automaticity induced by epinephrine. ETCG(0.01mg/L ,0 .043mg/L ,0 .17mg/L)prolonged functional refractory period obviously.
【关键词】 糖芥总甙；
左心房肌；
收缩性；
兴奋性；
功能性不应期；
自律性；
【Key words】 Erysium cheiranthoides L total cardiac glycosides； Left atrial muscle； Contractility； Excitability； functional refractory period；
【Key words】 Erysium cheiranthoides L total cardiac glycosides； Left atrial muscle； Contractility； Excitability； functional refractory period；
- 【文献出处】 中国药理学通报 ,Chinese Pharmacological Bulletin , 编辑部邮箱 ,1990年05期
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