【摘要】 Sur对缩宫素及高K⁺去极化后Ca⁺⁺所致大鼠离体子宫颈肌,人离体子宫颈肌均有明显抑制或松弛作用,对家兔在体子宫自发收缩活动亦具松弛作用,累积量效曲线表明,Sur与CaCl₂呈非竞争拮抗,Sur对缩宫素所致依细胞内Ca⁺⁺及细胞外Ca⁺⁺的收缩反应均有显著抑制作用Nif对两种收缩成份也具同样的抑制作用。更多还原

【Abstract】 Surazepam ( Sur ) is a benzodiazepine derivative. Sur ( 0.2~0.27m-mol/L ) inhibited the contraction of isolated cervices uteri of rats and human beings induced by oxytocin and Ca2+ after high K+ concentration depolarization Sur ( 3.5~ 4 mg/kg ) iv could also inhibit the spontaneous contraction of uterus of rabbit in situ. The cumulative dose-response curves for Sur and CaCl2 exhibited non-competition.Both Sur and nifedipine markedly inhibited extracellular and intra-cellular Ca2+ dependent contraction induced by oxytocin.更多还原