【摘要】 唐松草舒平安（Thalisopidine,thal）10mg/kg iv可显著提高哇巴因致豚鼠心律失常的用量;能显著降低iv CaCl₂大鼠的死亡率;预防氯仿引起小鼠心室纤颤的发生,并能对抗大鼠心肌缺血复灌所致的心律失常,但对乌头碱诱发大鼠心律失常的作用无效。小鼠恒速注射thal（0.37mg/min iv）,在注射的第3、4min PR间期显著延长,QRS增宽,HR减慢。Thal 10～20mg/kg iv降低麻醉大鼠SAP,DAP,LVP,+dP/dt,-dP/dt,HR,降压与抑制心肌收缩力作用时间较短,很快恢复到给药前水平。更多还原

【Abstract】 Thalisopidine ( thal) is a bisbenzylisoquinoline alkaloid isolated from Thalictrum isopyroides. It’s chemical structure is similar to tetrandrine and dauricine which have been reported to be antiarrhy-thmic and hypotensive agents .In the present study,the antiarrhythmic effects of thal were studied in several experimental models. Pretreat-ment with thal (10mg/kg iv ) significantly antagonized arrhythmias induced by ouabain in guinea pigs. It markedly prevented ventricular fibrillation induced by chloroform in mice and reduced the incidence of mortality produced by iv CaCl2 in rats but it lacks efficacy in aconitine-induced arrhythmias. It is also effective in preventing reperfusion-induced arrhythmias in aneasthetized rats. Thal (10~20mg /kg iv) lowered SAP, DAP, LVP, ± dP/dtmax and HR, but the changes of these parameters recovered to initial value rapidly.更多还原