【摘要】 在培养的兔主动脉平滑肌细胞（ASMC）中首次证实了酪氨酸蛋白激酶（TPK）的存在,并对ASMC增殖周期中TPK的活性变化进行了研究,从G₀期进入G₁期,酶活性逐渐下降,至G₁中期（6h）降至最低（56％）;随后上升,G₁晚期（12h）达到最高峰（156％）;DNA合成之前又降至G₀期水平（以G₀期酶活性作为100％）。结果提示TPK对ASMC的增殖具有促进作用。更多还原

【Abstract】 Tyrosine protein kinase (TPK) was first identified and its activity variation in cell cycle of cultured rabbit aortic smooth muscle cells(ASMC) was studied. With the entry of G0 cells into cell cycle, there was a decrease in TPK activity with the lowest point at 6hr (56%) and an increase in late G1 with a peak at 9hr (156%), regarding G0 TPK activity as 100%. This result suggests that TPK may play a positive effect on the proliferation of ASMC.更多还原