【摘要】 从超微结构方面研究了动物模型中三个煤种的煤尘与肺巨噬细胞的相互作用及其作用下的肺组织反应。煤尘在肺巨噬细胞中发生了诸如粉尘粒子边缘模糊,呈云雾状,电子密度不均,半壁消融等改变,但各煤种反应强度不一。巨噬细胞保持完好,细胞器增生,出现模一层结构,褐煤尘组肺组织自始至终出现显著的Ⅱ型细胞反应。煤尘同样能引起浆细胞反应及一些胶原纤维增生。吞噬了煤尘的退化的肺巨噬细胞有向纤维细胞转化的倾向。更多还原

【Abstract】 The ultrastructural changes of lungs tissue reaction of three kinds of dusts and their interaction with alveolar macrophages were studied in animal models. The changes of coal dusts in alveolar macrophages included: indistinct edge with cloudy appearance, uneven electron density, half side melt down etc. However, the intensity of reaction caused by three kinds of coal dusts was different with each other. The macrophages was intact, the organelles showed hyperplasia and membranelayer structure. The changes caused by brown coal dusts showed distinct type 2 pneumonocytos reaction throughoutly. Likewise coal dusts were able to elicit plasma cells reaction and certain collagen fibre proliferation.The degenerated alveolar macrophages which phagocytized coal dusts tended to transform into fibrocytes.更多还原