【摘要】 为阐明睾酮在鹿角柄发生过程中的作用机理,本文对6头梅花鹿的生茸区骨膜和头部的非生茸区骨膜的睾酮特异结合进行了测定。所得结果为,正常、去势雄仔鹿的生茸区骨膜中都存在一定量的睾酮特异结合(分别为:正常,细胞质为29.32,细胞核为169.63;去势,细胞核为595.84。单位:fmol/mg蛋白),而非生茸区骨膜却未测到这种特异结合;雌鹿的测定结果为,除去势雌仔鹿生茸区骨膜具有一定量的睾酮特异结合(细胞核为223.21fmol/mg蛋白)外,其余生茸区和非生茸区均不存在睾酮特异结合。这些结果表明,雄仔鹿和去势雌仔鹿生茸区骨膜中可能存在着一定量的雄激素受体,这种骨膜在特定的生理条件下受睾酮的直接作用,是睾酮的靶组织。更多还原

【Abstract】 The testosterone specific-binding in the antlerogenic and nonantle-rogenic site periosteum of six deer have been measured for illustrating the function of testosterone in the deer pedicle generation. For male deer, testosterone specific-binding was discovered in the antlerogenic site periosteum of intact deer ( 29.31 fmol/mg protein in cytoplasm and 169.63 fmol/mg protein in nuclei ) and castrated one ( 595.84 fmol/mg protein in nuclei ) , but not in the nonantlerogenic one of these deer; For female deer, only in the antlerogenic site periosteum of castrated fawn ( 223.21 fmol/mg protein in nuclei ) , while not in the antlerogenic and nonantlerogenic site periosteum of any other deer. These data suggest that a certain amount androgen receptors may exist in the antlerogenic site of male ( intact and castrated ) fawn and female one(only castrated ) and the receptor-contained periosteum as the target tissue of testosterone may be directly stimulated by testosterone.更多还原