【摘要】 本文报道了HPLC法测定释放左炔诺孕酮宫内节育器中的剩余药量。方法快速,简便。本方法采用YWG-C18柱,流动相为甲醇-水,紫外检测波长254nm。样品中左炔诺孕酮用氯仿萃取,以炔诺酮为内标,药物与内标峰面积比与剩余药量成良好线性关系,平均回收率为100.1±2.2％。本法适用于释放左炔诺孕酮宫内节育器体内释药规律的研究。更多还原

【Abstract】 A rapid and simple method for determinating levonorgestrel （LNG） remained in levonor-gestrel intrauterine device （LNG-IUD） by HPLC was reported. A YWG-C18 column, binarymobile phase （CH₃OH-H₂O）, and UV 254nm detecter were used. LNG in the IUD was extra-cted with chloroform. Norethindrone was used as an internal standard. There was a goodlinear relationship between the ratio of the areas of LNG and internal standard and the amo-unt of residual LNG. The mean recovery was 100.06±2.2%. This method is applicable invivo release study of LNG-IUD更多还原