【摘要】 为进一步明确急性肾小球肾炎(AGN)的发病机理,我们检测了AGN患儿外周血淋巴细胞白细胞介素-2(IL-2)活性及白细胞介素2受体(IL-2R)表达能力。结果表明AGN患儿外周血淋巴细胞IL-2活性低于对照组(P<0.05);经PHA刺激激活后的淋巴细胞IL-2R表达能力低于对照组(P<0.005);而未经PHA刺激的淋巴细胞IL-2R表达能力高于对照组(P<0.01)。提示该病的发生是由于患儿T淋巴细胞功能不足,免疫应答能力下降:T—B淋巴细胞功能失调,机体免疫调节功能紊乱的结果。更多还原

【Abstract】 The activity of interleukin-2 (IL-2) and expression of interleukin-2 receptor (IL-2 R) were measured in children with acute glomerulonephritis (AGN) in order to detemine the mechanism of the disease Our results showed that the activity of IL-2 in peripheral blood lymphocytes (PBL) of children with AGN was lower than that tof the control group (P<0.05), and the unmber of expression of IL-2 in PHA-stimulated PBL was also lower than that of the control grroup (P<0.005), while the number of spontaneous expression of IL-2R in UnstimulatedPBL was higher than that of the control group (P<0.01). The data suggested that the Occurrence of the disease might result from the decreased ability of cellular immune resparse due to the function impairment of the T lymphocytes and the disorder of the immunoregulation in children with AGN due to the function disorder of T-B lymphocytes.更多还原