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促性腺激素释放激素抗衰老作用的初步临床观察
CLINICAL OBSERVATION ON THE ANTI-AGING EFFECT OF GnRH
【摘要】 30例离退休老人,通过鼻喷雾器吸入GnRH,每日清晨一次,喷出量为100μg,历时6个月,作自身对照。结果表明,11个项目的脑力、体力以及性功能状况都有不同程度的改善(P<0.05)。肝功能、肾功能、血糖、血脂、血压、心功能、X线摄片、心电图8项检查也有不同程度的好转。但人体外观没有明显变化,作者认为GnRH改善健康状况可能通过调节垂体;作为一种神经递质或调质在中枢神经系统内起作用以及直接作用于外周器官而实现的。
【Abstract】 Serving as subjects of the present study, 30 retired persons(man 29; woman 1) within the age range of 55-72 years were given GnRH 50 μl (=100μg) by nasi-sprayer once each morning. Their subjective feeling, objective signs and laboratory examination were observed with dual blind method for six months, with normal saline given instead of GnRH in the control group. The results showed that in most of them 11 items of the subjec- tive feeling (including thinking ability, memory, calculating capacity, attention, bodily strength, hobby, appetite, sexual disire, social intercourse, mood, and sleep) had been improved in varying degrees after taking the medicine. There is a significant difference in contrast to that before taking it (P<0.05). But there is no significant difference in objective signs (the appearences of hair, skin, wrinkle, eyelid, auricle, oral cavity and body weight). In the laboratory examination, we observed 13 items, including 1. liver function, 2. kidney function, 3. blood glucose, 4. blood lipits, 5. EKG, 6. heart function, 7. blood presure, 8. X-ray on skull, 9. EEG, 10. ERG, 11. blood routine, 12. rheologic, and 13. B ultrasonic wave. In 8 former items, total 54 cases in the 36 items were improved (66.7%). Our tests illustrate that GnRH is able to improve human health and resiste aging to some extent, we think that the effect of GnRH is achieved by the mechnism of hypophysiotropin and outer hypophysis.
- 【文献出处】 皖南医学院学报 ,Mcta Academiae Medicinae Wannan , 编辑部邮箱 ,1990年01期
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