【摘要】 本文比较系统地介绍为放射免疫治疗用⁹⁰Sr-⁹⁰Y发生器的研制,各种分离、分析的条件实验。国产732型阳离子交换树脂成功地被用于⁹⁰Sr,⁹⁰Y的分离。得到的⁹⁰Y可满足医学临床应用要求,⁹⁰Y的去污因子为10⁶。本工艺简便、安全.每740MBq⁹⁰Y中,⁹⁰Sr杂质沾污仅为0.74kBq左右。⁹⁰Sr系剧毒性核素,人终身允许剂量为74kBq.若病人一次接受740MBq⁹⁰Y治疗。那么接受上百次治疗,方能达到其终身允许剂量。本发生器的淋洗效率可达98%,可推荐用于单克隆抗体的标记,临床放射免疫治疗。更多还原

【Abstract】 In recent years, ⁹⁰Y has been considered as one of the best radionuclides for tumor radioimmunotherapy when chelated to tumor-associated antibodies. This evaluation is based on the superior properties of this radionuclide （suitable half-life, pure β-ray emitter of intermediate energy, stable daughter, and suitable chemical properties） and because it is available as a radionuclide generator product by decay of its 28a parent ⁹⁰Sr.In this paper experimental conditions of the ⁹⁰Sr-⁹⁰Y generator are described. The elution efficiency of ⁹⁰Sr-⁹⁰Y generator reaches 98%. One of the most important problems is the ⁹⁰Sr contamination breakthrough from the generator. The level of ⁹⁰Sr contamination must be controlled to reach the clinical standard. The cation exchange resin 732（100—150 mesh）was successfully used for the separation of ⁹⁰Y from ⁹⁰Sr. Our method provides a ⁹⁰Y-HAc solution which is very simple and safe for administration to the patients. ⁹⁰y was separated from ⁹⁰St almost completely, the level of the ⁹⁰Sr contamination per 740MBq ⁹⁰Y product was only 0.74kBq. However the toxicity of ⁹⁰Sr is extremely high, the human life-time permissible dose is 74kBq,then 740MBq of ⁹⁰Y is allowed to be administrated to a patient for 50—100 times.更多还原