【摘要】 对24例心内直视术病人血浆纤维连接素测定,发现心肺转流术中纤维连接素下降44.4±10.17％,术后24h内恢复正常。其下降与下列因素有关:血液稀释;肝素作用;异物表面接触效应;纤维蛋白原凝集以及可能存在的纤维连接素对血小板保护。心肺转流术结束时纤维连接素水平越低,术后病人并发症越多,死亡率越高,通过输入新鲜血可提高病人血浆纤维连接素浓度,可能有利于术后病人的恢复。更多还原

【Abstract】 The concentration of plasma fibronectin was determined in 24 patients undergoing open heart surgery during cardiopulnionary bypass.Fibronectin level declined sharply (44.4±10.17%) 15 minutes after bypass was started,and returned to normal 24 hours postoperatively.The decrease in fibronectin was not solely due to blood dilution,but also due to the effect of heparin,foreign matter surface,coagulation of fibrinogen,clearance of FDP and cell debris.Protection of platelet from aggregation induced by collagen,thrombin etc.by fibronectin may also contribute to the decline.Our research has also shown that the lower the fibronectin level is,the more complications and the higher mortality of the patients take place after bypass and that the fibronectin level can be raised by blood transfusion,which may facilitate the patients’ recovery.更多还原