【摘要】 应用¹²⁵Ⅰ标记的人促甲状腺激素（hTSH）作为示踪配体,对29名正常人和18名Hashi-moto病（HTD）患者血清中抗hTSH自身抗体（TSHab）病行了检测;29名正常人TSHab指数（TSHabI）为0.85±0.22:而18名HTD患者TSHabI为1.37±0.39（x±s,P<0.01）。SPA菌体结合沉淀试验表明:这种与hTSH结合的抗体属于IgG成份。TSHab的存在提示:HTD的兔疫学发病及其转归可能涉及垂体和独特型、抗独特型反应机制。更多还原

【Abstract】 The hTSHab have been detected in 29 normal subjects and 18 patients with Hashimoto’s disease by using 125I-TSH as a tracing reagent.The hTSHab index (hTSHabl) was 0.85±0.22 in normal subjects and 1.37±0.39 (P<0.01) in patients with HTD.The results of staphylococcus aureus cowan I precipitation assay show that the antibodies binding to hTSH belong to IgG The existence of hTSHab in HTD suggested that the reaction of idiotype/anti-idiotype and pituitary might be involved in the autoimmune mechanism of HTD.更多还原