【摘要】 作者对 HBsAg 和 HBeAg 均阳性的孕妇所生婴儿分别用国产乙肝疫苗和美国 Merck产乙肝疫苗进行免疫。在12个月龄时,前者采血23例,HBsAg 阳性者5例。后者采血16例,HBsAg阳性者也是5例。保护率分别为75.9%和65.2%。12个月龄时的抗-HBs 阳性率国产乙肝疫苗和Merck 乙肝疫苗分别为77.3%和60.0%(X~2=0.3,P=0.4),GMT 各为544.2和470.0mIU/ml(X~2=0.3,P>0.05),两者均无显著性差异。更多还原

【Abstract】 Two batchs of vaccine,one produced by Shanghai Institute of Biological Products(Lot 8510,HBsAg 20μg/ml)and the other by Merck Sharpe and Dohme, USA(Lot 1061L,HBsAg 20μg/ml)were used.The first injection was given within the first 24h after delivery of the infants,the second and third injection at 1 and 6 months of age respectively. 37 infants born to hepatitis B surface antigen(HBsAg)and hepatitis B e antigen (HBeAg)positive mothers participated in this study.5 of 16 recipients who received Merck vaccine and 5 of 23 recipients who received Shanghai vaccine were converted to HBsAg positive at 12 months of age.The protective rates were 65.2% and 75.9% respectively.The anti-HBs cumulative seroconversion to the two vaccines at 12 mo- nths of age was 60.0% and 77.3% and the geometric mean titer(GMT)was 470.0 and 544.2 mIU/ml respectively. No significant difference was found between these two vaccines,produced by di- fferent manufacturers.更多还原