【摘要】 本文研究了水杨酸对人工膜脂质过氧化的抑制效应.实验结果表明,水杨酸能抑制磷脂酰胆碱脂质体的过氧化,减少丙二醛的形成,自旋捕集实验表明,水杨酸能(火卒)灭氢氧自由基和超氧阴离子自由基.质谱分析对水杨酸与氢氧自由基的反应产物进行了鉴定,证明产物为二羟基发甲酸.对水杨酸(火卒)灭氢氧自由基的机理进行了讨论.更多还原

【Abstract】 The inhibitory effect of salicylic acid on the lipid per-oxidation in pho-sphatidylcholine liposomes by salicylic acid has been studied. Results show that salicylic acid inhibits the lipid peroxidation and reduces the formation of ma-londialdehyde in phosphatidylcholine liposomes. Spin trapping experiments show that salicylic acid can scavenge the hydroxyl radicals and superoxide radicals. Mass spectroscopic analysis evidence is presented that the reaction product of salicylic acid with hydroxyl radicalis dihydrobenzoic acid. The possible mechanism of those reaction also has been discussed.更多还原