【摘要】 <正> 自Gil-Av等人用氨基酸固定相成功地分离了一些氨基酸对映体以来,出现了多种类型的手性固定相,有肽、酰胺和金属螯合物等。其中使用最多的是二酰胺更多还原

【Abstract】 In this work,four chirai stationary phases (CSPs) were investigated.The enantioselectivity of CSP-1(C6H5 CH2OOC-CH2CH2CO-L-Val-tert-butylamide)isnot only the best to proline among the phases used,but also good to ordinary protein amino acids.CSP-2(CH2=CH(CH2)8CO-L-Val-S-α-PhenylethyIa mide) and CSP-3(CH2=CH(CH2)8CO-L-Val-R-α-phenylethylamide) are diastereoisomers with two asymmetric carbons.The elution of D,L-enantiomers of α-amino acids en CSP-2 and CSP-3 is in reversed order.With a polymer as a substrate,CSP-4(OV-225-L-Val-tert.-hulylamide) has both high enantioselectivity and thermal stability.The relationship between CSP structures and their enamiosdectivity and elution order are discussed.更多还原