【摘要】 对6例血清HAV阳性的甲肝患者,在其ALT下降后做肝穿刺,进行光镜、电镜及免疫酶标检测。光镜见肝细胞有水肿变性,门管区附近嗜酸性小体形成,同时有肝细胞增生,可见核肿大及核内假包涵体,门管区有明显的炎细胞浸润。电镜特点为线粒体高度凝聚性变或肿胀,粗面内质网作同心环层排列在线粒体周围或扩大成小囊。胞质内有髓样小体。核内有胞质突入形成的假包涵体。免疫酶标检查,由于穿刺时发病超过G周,故未找到HAAg阳性细胞。根据观察所见,作者认为甲肝功能的恢复较形态恢复为早,组织的损害时间持续较长,细胞的损害与增生往往同时存在。细胞的电镜变化,早期以内质网改变明显,恢复期以线粒体为主。此外,对甲型和乙型肝炎的区别作了简要讨论。更多还原

【Abstract】 Liver puncture biopsy was performed in 6 serum HAV positive patients when their ALT resumed normal value. Under light microscope, the specimens showed hydropic degeneration, eosinophilic bodies formed, proliferation of hepatocytes, swelling of nuclei, and some pseudo-inclusion bodies within nuclei. Under electron microscope, there were swelling and condensed conformations in mitochondria. Some rough-endoplasmic-reticulum (RER)dilated into a vesicle and some medulla bodies were seen in cytoplasm of hepatocytes. Occasionally cytoplasm invaded into nuclei forming pseudo-inclusion body. Immunological examination of slides was negative in this stage.The authors conclude that functional recovery is earlier than morphologic recovery and histologic damage and repair occur concurrently in hepatocytes.更多还原