【摘要】 我们用四氧嘧啶诱导糖尿病大鼠动物模型,研究病程为4、8、12周的糖尿病大鼠和同龄正常大鼠肾皮质和外髓葡萄糖、果糖、山梨醇、肌醇含量和Na-K-ATP酶活性变化。各病程糖尿病火鼠与同龄正常对照组比较,肾组织葡萄糖、果糖、山梨醇含量和Na-K-ATP酶活性均非常显著性增高(P<0.01),肌醇含量无统计学差异,且各病程糖尿病大鼠伴有肾脏肥大。这些变化可能对糖尿病发生肾脏病变有一定作用,但糖尿病肾脏组织与外周神经组织的多元醇通路活性和Na-K-ATP酶活性变化的关系不同。更多还原

【Abstract】 Alterations of polyol pathway, myo-inositol metabolism and Na-K-ATPase are part if a unifying hypothesis proposed to explain the pathogenesis of the chronic complicaoions of diabetes mellitus. To test whether the hypothesis could be applied to diabetic nephropathy, we measured the glucose, fructose, sorbitol and myo-inositol contents and Na-K-ATPase activity in homogenates of renal cortex and outer medulla of rats with diabetes for 4, 8 and 12 weeks in comparison with age-matched control, the fructose, glucose, and sorbitol contents and Na-K-ATPase activity in diabetic kidney were significantly increased (P<0.01), but myo-inositol contents showed no difference. There was renalhypertrophy in diabetic rats. These results suggest that the rise of polyol pathway and Na-K-ATPase activity may have the pathogenetic significance for diabetic nephropathy, although the relationship between polyol pathway and Na-K-ATPase activity changes in the kidney of diabetic rats was different from that in the peripheral nerve of diabetic rats.更多还原