【摘要】 本文从加拿大引进纯系色BB/Wistar大鼠,在国内首次建立自发性遗传性糖尿病BB鼠模型,对其发病特点以及胰岛病变进行研究。本文自发性糖尿病BB鼠的发病率为16.6％,发病鼠的血糖及糖基化血浆蛋白水平均明显增高。胰岛明显破坏,B细胞数量明显减少,大量脱β颗粒,胞浆肿胀。这些病变与人类胰岛素依赖型糖尿病(IDDM)的病变十分相似,提示糖尿病BB鼠是一种理想的IDDM动物模型。更多还原

【Abstract】 A pure BioBreeding (BB)/Wistar rat model of spontaneous genetic diabetes was introduced from Canada.They reproduced locally. Clinical features and pathological islet changes in these diabetic rats were studied. In this study, the incidence of spontaneous diabetes in the rats was 16.6%. Blood glucose and glycosyla-ted plasma protein levels were found to be significantly increased in the diabetic rats. Islet B cells showed serious demage, and obvious decrease. There were marked depletion of β granules and marked cytoplasmic swelling in these B cells. These changes in the diabetic rats closely simulated those in human insulin-dependent diabetes mellitus (IDDM). These results suggest that the diabetic BB rat may be an ideal IDDM animal model.更多还原