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河豚毒素和Cd2+对Zn2+诱发爆发波放电的影响
THE INFLUENCE OF TETRODOTOXIN AND Cd2+ ON BURST DISCHARGES EVOKED BY Zn2+
【摘要】 本文用微电极细胞内电位记录、通道阻断剂和放射性同位素等技术发现,锌离子可诱发爆发波放电(BD),钠通道阻断剂——河豚毒素对BD无效应,而钙通道阻断剂——Ca2+则可使BD消失,Cd2+可使[65Zn2+];量减少。以上结果说明,Zn2+诱发BD的产生机理很可能是Zn2+代替Ca2+通过钙通道进入胞内引起的。
【Abstract】 The intracellular microelectrode recording technique, channel blocker and radioisotope tracer method were used. The burst discharges were evoked by Zn2+, no change by sodium channel blocker——Tetrodotoxin, but abolished by calcium channel blocker——Cd2+. [65Zn2+]; was decreased by Cd2+. It is possible, that Zn2+, instead of Ca2+, goes into cells through calcium channels in the mechanism of BD evoked by Zn2+.
- 【文献出处】 生物化学与生物物理进展 ,Progress In Biochemistry and Biophysics , 编辑部邮箱 ,1990年02期
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