【摘要】 藏药雪灵芝水提液4g/kg sc,有抑制巴豆油诱发小鼠耳部水肿和大鼠肉芽肿以及炎症渗出液的作用,对蛋清法和角叉菜胶诱发的大鼠足肿胀急性炎症也有明显的抑制作用,抗炎作用强度与可的松相近。雪灵芝5g/kg sc,可抑制小鼠腹腔巨噬细胞的吞噬作用和血清半数溶血值,并可减轻胸腺、脾脏重量。雪灵芝的抗免疫作用类似可的松,但随着剂量增大,则出现免疫增强效应。初步认为雪灵芝是一种免疫调节剂。为了探讨雪灵芝的抗炎作用机理,测定了肉芽肿大鼠的血液¹²I皮质醇含量,雪灵芝组含量明显低于对照组,说明雪灵芝不是通过刺激肾上腺皮质释放糖皮质激素而发挥的抗炎作用,而是皮质醇样直接抗炎作用。雪灵芝还有较强的解热,镇痛作用。更多还原

【Abstract】 4g/kg, SC of the water extract of the Tibetan drug, Arenaria, can inhibit the edema in the ears of mice induced by Croton oil and granujoma in rats as well as fluid infiltrated from inflammation. It also has significant inhibit effect on acute inflammation swollen area in the feet with claws of rats induced by albumen injection and carrageenan. The effect of this Tibetan drug is nearly the same as that of cortisone. 5g/kg, SC of Arenaria can inhibit the phagocytosis of the histocytes in the abdomen of mice and serum HC50. Besides., it may decrease the size of thymus and the weight of spleen. This is another fact to prove that the effect of Arenaria is comparable to that of cortisone. With the increase of the does, the stronger is the immulogical ability. Therefore it is primarily concluded that Aren- aria is one kind of regulatory drugs for immunity. For the purpose of investigation of the mechanism of the antiinflammation effect of Arenaria, the authors have measured the amount of I¹²⁵ cortisol in blood of rats with granuloma. The amount of cortisol is significantly lower in Arenaria group than that of the control group. This indicates that the ant iinflammat ion effect is not produced by the released glucocort i coid from the stimulated adrenal cortex but the direct effect of the Tibetan drug to overcome the inflammation, Additionally, Arenaria has stronger role in relief of fever and in ease of pain.更多还原