【摘要】 适当减少棉酚服药量不仅可缓解毒副反应,抗生育可逆性也得以改善。6名服药者停药一年精子计数、活动率及穿卵率全部恢复正常水平。精子LDH-C₄与对照未见明显差异。更多还原

【Abstract】 Recent clinical study showed that side effects of gossypol as a male contraceptive could be avoided by lowering the dosage to sixty percent of the dose used in previous studies,In order to evaluate the reversibility of antifertility effect of the low-dose gossypol, we conducted a one-year follow-up study in 6 participants who had taken low dose gossypol for 1 or 1.5 years. Six months after discontinuation, spermatogenesis in all the participants showed obvious recovery, with one case resulted in pregnancy.One year after discontinuation, the sperm count, sperm motility and sperm-egg penetration rates of all the 6 men recovered to within the normal range. In addition, sperm LDH-C₄ was determined by histochemical method which revealed no significant difference between gossypol users and controls.更多还原