【摘要】 观察了雷公藤多甙(T_Ⅱ)对柔红霉素肾病大鼠肾皮质丙二醛(MDA)、血清MDA、尿蛋白和肾脏病理组织学的影响:T_Ⅱ显著降低柔红霉素肾病大鼠尿蛋白、肾皮质MDA和血清MDA,肾脏病理组织学改变也明显减轻,这些变化类似于自由基清除剂(超氧化物歧化酶、过氧化氢酶和维生素E)对该模型的影响。结果提示T_Ⅱ具有清除氧自由基和(或)阻断脂质过氧化反应作用,可能是T_Ⅱ抗炎机制所在。更多还原

【Abstract】 The effects of total glycoside of T.Wilfordii(T_Ⅱ)on renal cortical malondialdehyde (MDA),serum MDA,urinary protein excretion and pathology of kidney of rats with daunomycin nephrosis(DMNS)were investigated.The results showed that T_Ⅱ could significantly reduce the level of albuminuria,renal MDA,and serum MDA of rats with DMNS.The change of renal pathology of Ta-treated rats with DMNS was less than that of rats with DMNS.All these alterations resembled the effect of free-radical scavengers(e.g., superoxide dismutase,catalase,and vitamin E)on rats with DMNS reported in previous articles.T_Ⅱ possesses potential function of scavenging free radical oxygen species and/or inhibiting lipid peroxidation as suggested by the results may be the mechanism responsible for its therapeutic action.更多还原