【摘要】 兔病毒性出血症是兔的一种败血性传染病,通过电镜观察和免疫胶体金-银法的监测,病毒最先侵害的靶器官是肝、脾和肺,然后到达全身血流,最后分布到其它器官。发现动物在感染后18～24小时,在肝、脾、肺、肾和肠上皮细胞、血管壁内皮细胞、循环的中性白细胞、淋巴细胞及肥大细胞的核内有病毒颗粒,其直径为32～34nm,无囊膜。感染后24小时直到死亡前,大部分病毒颗粒被释放到细胞浆和间质中去。初步认为本病是由于病毒血症对各器官的直接损伤,尤其对血管壁的损伤,导致全身弥散性血管内凝血(DIC)及全身性出血。由于血液的丧失,继而使全身各器官发生缺氧,最终引起生命重要器官的功能衰竭而死亡。更多还原

【Abstract】 Rabbit Viral Heamorrhage Disease(RVHD)was a septic disease.Based on the obser-vation by electron microscope and monitoring by immuno gold-silver stain,the virus firstinvaded the target organs including liver,spleen and lung,then reached the blood streamand finally infected other organs,The virions were found with in nuclei of liver,spleen,lung,kidney,intestinal epithelium,endothelium of vassal wall,ciculating neutrophils,lymphcytes and mast cells 18～24 hours after infection.The virions are 32～34 nm in diameterand non-enveloped.They were released to cytoplasm and mesenchyma 24 hours after infec-tion till death.The cause of death was that the viremia directly induced injury of different or-gans and vassal wall,then results in disseminated intravascular coagulation(DIC)andsystemic heamorrhage,and that blood loss caused hypoxia of systemic organs,and finallyinduced functional failure in vital important organs.更多还原