【摘要】 本实验研究了环磷酰胺和LAK细胞被动输入联合应用对SHR大鼠乳腺癌肺转移的影响。结果表明当投给50mg/kg环磷酰胺和被动输入LAK细胞(4×10~7/只)可以明显地抑制SHR大鼠乳腺癌的肺转移(P<0.01),并且能有效地延长荷瘤动物的生存时间(P<0.01);半治疗量的LAK细胞和环磷酰胺具有协同抗转移作用(P<0.05)。提示此方法是一个有效的免疫化学疗法。更多还原

【Abstract】 We investigated the effect of cyclophosphomide combined with transferred LAK cells on pulmonary metastasis of SST- 2 mammary carcinoma in SHR rats. It has been shown that when combination of cyclophosphomide and passive transferred LAK cells led to a significant inhibition on experimental pulmonary metastasis of the mammary carcinoma in SHR rats(P<0.01), and to improve the survival of animal bearing SST-2 tumor cells (P<0.01); A half quantity of LAK cells could led to synergistically increased effect of cyclophosphomide on antimetastasis (P<0.05) . The results suggest that it could provide a immuno-chemotherapy for tumor and metastasis.更多还原